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Combined ascorbate and glutathione deficiency leads to decreased cytochrome b(5) expression and impaired reduction of sulfamethoxazole hydroxylamine
Sulfonamide antimicrobials such as sulfamethoxazole (SMX) have been associated with drug hypersensitivity reactions, particularly in patients with AIDS. A reactive oxidative metabolite, sulfamethoxazole-nitroso (SMX-NO), forms drug-tissue adducts that elicit a T cell response. Antioxidants such as a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910208/ https://ncbi.nlm.nih.gov/pubmed/20221587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-010-0530-z |
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