Combined ascorbate and glutathione deficiency leads to decreased cytochrome b(5) expression and impaired reduction of sulfamethoxazole hydroxylamine

Sulfonamide antimicrobials such as sulfamethoxazole (SMX) have been associated with drug hypersensitivity reactions, particularly in patients with AIDS. A reactive oxidative metabolite, sulfamethoxazole-nitroso (SMX-NO), forms drug-tissue adducts that elicit a T cell response. Antioxidants such as a...

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Bibliographic Details
Main Authors: Bhusari, Sachin, Abouraya, Mahmoud, Padilla, Marcia L., Pinkerton, Marie E., Drescher, Nicholas J., Sacco, James C., Trepanier, Lauren A.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910208/
https://ncbi.nlm.nih.gov/pubmed/20221587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-010-0530-z
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