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Reversible Reduction of Nitroxides to Hydroxylamines: the Roles for Ascorbate and Glutathione

Biological applications of stable nitroxyl radicals, NR, include their use as contrast agents for magnetic resonance imaging, spin labels, superoxide dismutase mimics, and antioxidants. The rapid reduction of NR in biological samples into hydroxylamines, HA, significantly limits their application. I...

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Detalhes bibliográficos
Principais autores: Bobko, Andrey A., Kirilyuk, Igor A., Grigor'ev, Igor A., Zweier, Jay L., Khramtsov, Valery V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829321/
https://ncbi.nlm.nih.gov/pubmed/17210453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2006.11.007
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