In Vivo Monitoring of pH, Redox Status, and Glutathione Using L-Band EPR for Assessment of Therapeutic Effectiveness in Solid Tumors

Approach for in vivo real-time assessment of tumor tissue extracellular pH (pH(e)), redox, and intracellular glutathione based on L-band EPR spectroscopy using dual function pH and redox nitroxide probe and disulfide nitroxide biradical, is described. These parameters were monitored in PyMT mice bea...

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Autori principali: Bobko, Andrey A., Eubank, Timothy D., Voorhees, Jeffrey L., Efimova, Olga V., Kirilyuk, Igor A., Petryakov, Sergey, Trofimiov, Dmitrii G., Marsh, Clay B., Zweier, Jay L., Grigor’ev, Igor A., Samouilov, Alexandre, Khramtsov, Valery V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305854/
https://ncbi.nlm.nih.gov/pubmed/22113626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.23196
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