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Reversible Reduction of Nitroxides to Hydroxylamines: the Roles for Ascorbate and Glutathione

Biological applications of stable nitroxyl radicals, NR, include their use as contrast agents for magnetic resonance imaging, spin labels, superoxide dismutase mimics, and antioxidants. The rapid reduction of NR in biological samples into hydroxylamines, HA, significantly limits their application. I...

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Hlavní autoři: Bobko, Andrey A., Kirilyuk, Igor A., Grigor'ev, Igor A., Zweier, Jay L., Khramtsov, Valery V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829321/
https://ncbi.nlm.nih.gov/pubmed/17210453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2006.11.007
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