Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b(5)/NADH-b(5) Reductase in Variability of CYP3A Activity in Human Liver Microsomes

NADPH-cytochrome P450 reductase (CPR) and cytochrome-b(5) (b(5)) together with NADH-b(5) reductase (b(5)R) play important roles in cytochrome P450 3A-mediated drug metabolism via electron transfer. However, it is not clear whether variability in expression of these accessory proteins contributes to...

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Main Authors: Gan, Lu, von Moltke, Lisa L., Trepanier, Lauren A., Harmatz, Jerold S., Greenblatt, David J., Court, Michael H.
格式: Artigo
語言:Inglês
出版: American Society for Pharmacology and Experimental Therapeutics 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610240/
https://ncbi.nlm.nih.gov/pubmed/18838505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.023424
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