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Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron.

1. The metabolism of granisetron was investigated in human liver microsomes to identify the specific forms of cytochrome P450 responsible. 2. 7-hydroxy and 9'-desmethyl granisetron were identified as the major products of metabolism following incubation of granisetron with human liver microsome...

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Autores principales: Bloomer, J C, Baldwin, S J, Smith, G J, Ayrton, A D, Clarke, S E, Chenery, R J
Formato: Artigo
Lenguaje:Inglês
Publicado: 1994
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1364919/
https://ncbi.nlm.nih.gov/pubmed/7888294
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