Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients

AIMS: To compare the O- (CYP2D6 mediated) and N- (CYP3A4 mediated) demethylation metabolism of tramadol between methadone and buprenorphine maintained CYP2D6 extensive metabolizer subjects. METHODS: Nine methadone and seven buprenorphine maintained subjects received a single 100 mg dose of tramadol...

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Detalhes bibliográficos
Main Authors: Coller, Janet K, Michalakas, Jennifer R, James, Heather M, Farquharson, Aaron L, Colvill, Joel, White, Jason M, Somogyi, Andrew A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495148/
https://ncbi.nlm.nih.gov/pubmed/22369095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04256.x
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