Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects

AIMS: To compare the O-demethylation (CYP2D6-mediated), N-demethylation (CYP3A4-mediated) and 6-glucuronidation (UGT2B4/7-mediated) metabolism of codeine between methadone- and buprenorphine-maintained CYP2D6 extensive metabolizer subjects. METHODS: Ten methadone- and eight buprenorphine-maintained...

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Detalhes bibliográficos
Main Authors: Gelston, Eloise A, Coller, Janet K, Lopatko, Olga V, James, Heather M, Schmidt, Helmut, White, Jason M, Somogyi, Andrew A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Drug Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403206/
https://ncbi.nlm.nih.gov/pubmed/22092298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04145.x
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