Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes

AIMS: The present study was designed to define the kinetic behaviour of sertraline N-demethylation in human liver microsomes and to identify the isoforms of cytochrome P450 involved in this metabolic pathway. METHODS: The kinetics of the formation of N-demethylsertraline were determined in human liv...

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Detalhes bibliográficos
Main Authors: Xu, Zhen-Hua, Wang, Wei, Zhao, Xue-Jun, Huang, Song-Lin, Zhu, Bing, He, Nan, Shu, Yan, Liu, Zhao-Qian, Zhou, Hong-Hao
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014324/
https://ncbi.nlm.nih.gov/pubmed/10510155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00023.x
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