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Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans
AIMS: To assess the utility of human hepatic microsomes for predicting in vivo intrinsic clearance (CL(int)) via the use of four cytochrome P450 2C9 substrates: phenytoin, tolbutamide (S)-ibuprofen (two pathways) and diclofenac, and to examine the role of exogenous albumin within the microsomal incu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014252/ https://ncbi.nlm.nih.gov/pubmed/10383540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00935.x |
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