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Decreased Warfarin Clearance with the CYP2C9 R150H (*8) Polymorphism
The cytochrome P450 (CYP) 2C9 R150H (*8) allele occurs commonly in African Americans and is associated with lower warfarin dose requirements. We examined whether the CYP2C9*8 allele impacts warfarin clearance through a pharmacokinetic study in warfarin-treated African American patients and an in vit...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3879795/ https://ncbi.nlm.nih.gov/pubmed/22378156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.269 |
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