Novel SNP in CYP2C9 is associated with changes in warfarin clearance and CYP2C9 expression levels in African Americans

Warfarin is a widely used anticoagulant whose active S-enantiomer is primarily metabolized by the CYP2C9 enzyme. The CYP2C9*2 and CYP2C9*3 alleles are associated with lower warfarin dose requirement and decreased enzyme activity. In contrast, we previously identified a novel SNP (rs7089580 A>T) i...

Full description

Saved in:
Bibliographic Details
Published in:Transl Res
Main Authors: Hernandez, W, Aquino-Michaels, K, Drozda, K, Patel, S, Jeong, H, Takahashi, H, Cavallari, LH, Perera, MA
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433569/
https://ncbi.nlm.nih.gov/pubmed/25499099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2014.11.006
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items