Decreased Warfarin Clearance with the CYP2C9 R150H (*8) Polymorphism

The cytochrome P450 (CYP) 2C9 R150H (*8) allele occurs commonly in African Americans and is associated with lower warfarin dose requirements. We examined whether the CYP2C9*8 allele impacts warfarin clearance through a pharmacokinetic study in warfarin-treated African American patients and an in vit...

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Hlavní autoři: Liu, Yong, Jeong, Hyun-Young, Takahashi, Harumi, Drozda, Katarzyna, Patel, Shitalben R., Shapiro, Nancy L., Nutescu, Edith A., Cavallari, Larisa H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879795/
https://ncbi.nlm.nih.gov/pubmed/22378156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.269
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