CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes

AIM: To determine the Michaelis-Menten kinetics of hydrocodone metabolism to its O- and N-demethylated products, hydromorphone and norhydrocodone, to determine the individual cytochrome P450 enzymes involved, and to predict the in vivo hepatic intrinsic clearance of hydrocodone via these pathways. M...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hutchinson, Mark R, Menelaou, Andrew, Foster, David J R, Coller, Janet K, Somogyi, Andrew A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Drug Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884456/
https://ncbi.nlm.nih.gov/pubmed/14998425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.02002.x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados