The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects

AIMS: Rosiglitazone, a thiazolidinedione antidiabetic medication used in the treatment of Type 2 diabetes mellitus, is predominantly metabolized by the cytochrome P450 (CYP) enzyme CYP2C8. The anti-infective drug trimethoprim has been shown in vitro to be a selective inhibitor of CYP2C8. The purpose...

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Detalhes bibliográficos
Main Authors: Hruska, M W, Amico, J A, Langaee, T Y, Ferrell, R E, Fitzgerald, S M, Frye, R F
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Drug Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884957/
https://ncbi.nlm.nih.gov/pubmed/15606443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02263.x
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