Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects

AIM: To investigate a potential interaction between cranberry juice and diclofenac, a substrate of CYP2C9. METHODS: The inhibitory effect of cranberry juice on diclofenac metabolism was determined using human liver microsome assay. Subsequently, we performed a clinical trial in healthy human subject...

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Detalhes bibliográficos
Main Authors: Ushijima, Kentarou, Tsuruoka, Shu-ichi, Tsuda, Hidetoshi, Hasegawa, Gohki, Obi, Yuri, Kaneda, Tae, Takahashi, Masaki, Maekawa, Tomohiro, Sasaki, Tomohiro, Koshimizu, Taka-aki, Fujimura, Akio
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767282/
https://ncbi.nlm.nih.gov/pubmed/19694738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03436.x
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