Effect of ketoconazole on the pharmacokinetics of rosiglitazone in healthy subjects

AIMS: Fungal infection is a significant comorbidity in patients with diabetes mellitus, and ketoconazole, an antifungal agent, causes a number of drug interactions with coadministered drugs. Rosiglitazone is a novel thiazolidinedione antidiabetic drug, mainly metabolized by CYP2C8 and to a lesser ex...

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Autores principales: Park, Ji-Young, Kim, Kyoung-Ah, Shin, Jae-Gook, Lee, Ki Young
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2004
Materias:
Drug Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884597/
https://ncbi.nlm.nih.gov/pubmed/15373932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02161.x
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