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Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping
Structure-guided drug discovery emerged in the 1970s and 1980s, stimulated by the three-dimensional structures of protein targets that became available, mainly through X-ray crystal structure analysis, assisted by the development of synchrotron radiation sources. Structures of known drugs or inhibit...
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| Publicado en: | Philos Trans A Math Phys Eng Sci |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Royal Society Publishing
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6501894/ https://ncbi.nlm.nih.gov/pubmed/31030650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsta.2018.0422 |
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