Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin–cubilin complex and transferrin receptor 1

Receptor-mediated endocytosis is responsible for reabsorption of transferrin (Tf) in renal proximal tubules (PTs). Although the role of the megalin–cubilin receptor complex (MCRC) in this process is unequivocal, modalities independent of this complex are evident but as yet undefined. Here, using imm...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Smith, Craig P., Lee, Wing-Kee, Haley, Matthew, Poulsen, Søren B., Thévenod, Frank, Fenton, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497946/
https://ncbi.nlm.nih.gov/pubmed/30833328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006390
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