Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin–cubilin complex and transferrin receptor 1

Receptor-mediated endocytosis is responsible for reabsorption of transferrin (Tf) in renal proximal tubules (PTs). Although the role of the megalin–cubilin receptor complex (MCRC) in this process is unequivocal, modalities independent of this complex are evident but as yet undefined. Here, using imm...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Smith, Craig P., Lee, Wing-Kee, Haley, Matthew, Poulsen, Søren B., Thévenod, Frank, Fenton, Robert A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497946/
https://ncbi.nlm.nih.gov/pubmed/30833328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006390
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