Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin–cubilin complex and transferrin receptor 1

Receptor-mediated endocytosis is responsible for reabsorption of transferrin (Tf) in renal proximal tubules (PTs). Although the role of the megalin–cubilin receptor complex (MCRC) in this process is unequivocal, modalities independent of this complex are evident but as yet undefined. Here, using imm...

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Udgivet i:J Biol Chem
Main Authors: Smith, Craig P., Lee, Wing-Kee, Haley, Matthew, Poulsen, Søren B., Thévenod, Frank, Fenton, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497946/
https://ncbi.nlm.nih.gov/pubmed/30833328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006390
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