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Computational study of protein specificity: The molecular basis of HIV-1 protease drug resistance
Drug resistance has sharply limited the effectiveness of HIV-1 protease inhibitors in AIDS therapy. It is critically important to understand the basis of this resistance for designing new drugs. We have evaluated the free energy contribution of each residue in the HIV protease in binding to one of i...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The National Academy of Sciences
2001
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC64962/ https://ncbi.nlm.nih.gov/pubmed/11752442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251265598 |
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