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Transition states of native and drug-resistant HIV-1 protease are the same

HIV-1 protease is an important target for the treatment of HIV/AIDS. However, drug resistance is a persistent problem and new inhibitors are needed. An approach toward understanding enzyme chemistry, the basis of drug resistance, and the design of powerful inhibitors is to establish the structure of...

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Detalhes bibliográficos
Main Authors: Kipp, D. Randal, Hirschi, Jennifer S., Wakata, Aya, Goldstein, Harris, Schramm, Vern L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340095/
https://ncbi.nlm.nih.gov/pubmed/22493227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202808109
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