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Transition states of native and drug-resistant HIV-1 protease are the same
HIV-1 protease is an important target for the treatment of HIV/AIDS. However, drug resistance is a persistent problem and new inhibitors are needed. An approach toward understanding enzyme chemistry, the basis of drug resistance, and the design of powerful inhibitors is to establish the structure of...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340095/ https://ncbi.nlm.nih.gov/pubmed/22493227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202808109 |
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