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Transition States and Transition State Analogue Interactions with Enzymes

Enzymatic transition states have lifetimes of a few femtoseconds (fs). Computational analysis of enzyme motions leading to transition state formation suggests that local catalytic site motions on the fs time scale provide the mechanism to locate transition states. An experimental test of protein fs...

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Bibliografiske detaljer
Udgivet i:Acc Chem Res
Hovedforfatter: Schramm, Vern L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482137/
https://ncbi.nlm.nih.gov/pubmed/25848811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.accounts.5b00002
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