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Transition States, Analogues and Drug Development
Enzymes achieve their transition states by dynamic conformational searches on the fsec to psec timescale. Mimics of reactants at enzymatic transition states bind tightly to enzymes by stabilizing the conformation optimized through evolution for transition state formation. Instead of forming the tran...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3560411/ https://ncbi.nlm.nih.gov/pubmed/23259601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300631k |
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