Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs

Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) inf...

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發表在:Antimicrob Agents Chemother
Main Authors: Broeckel, Rebecca, Sarkar, Sanjay, May, Nicholas A., Totonchy, Jennifer, Kreklywich, Craig N., Smith, Patricia, Graves, Lee, DeFilippis, Victor R., Heise, Mark T., Morrison, Thomas E., Moorman, Nathaniel, Streblow, Daniel N.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2019
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496153/
https://ncbi.nlm.nih.gov/pubmed/30917980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02325-18
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