Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs

Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) inf...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Broeckel, Rebecca, Sarkar, Sanjay, May, Nicholas A., Totonchy, Jennifer, Kreklywich, Craig N., Smith, Patricia, Graves, Lee, DeFilippis, Victor R., Heise, Mark T., Morrison, Thomas E., Moorman, Nathaniel, Streblow, Daniel N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496153/
https://ncbi.nlm.nih.gov/pubmed/30917980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02325-18
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