Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs

Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) inf...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Broeckel, Rebecca, Sarkar, Sanjay, May, Nicholas A., Totonchy, Jennifer, Kreklywich, Craig N., Smith, Patricia, Graves, Lee, DeFilippis, Victor R., Heise, Mark T., Morrison, Thomas E., Moorman, Nathaniel, Streblow, Daniel N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496153/
https://ncbi.nlm.nih.gov/pubmed/30917980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02325-18
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