Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness

The global spread of Plasmodium falciparum chloroquine resistance transporter (PfCRT) variant haplotypes earlier caused the widespread loss of chloroquine (CQ) efficacy. In Asia, novel PfCRT mutations that emerged on the Dd2 allelic background have recently been implicated in high-level resistance t...

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Pubblicato in:mBio
Autori principali: Dhingra, Satish K., Gabryszewski, Stanislaw J., Small-Saunders, Jennifer L., Yeo, Tomas, Henrich, Philipp P., Mok, Sachel, Fidock, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495381/
https://ncbi.nlm.nih.gov/pubmed/31040246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02731-18
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