Gli1(+) mesenchymal stromal cells are a key driver of bone marrow fibrosis and an important cellular therapeutic target

Bone marrow fibrosis (BMF) develops in various hematological and non-hematological conditions and is a central pathological feature of myelofibrosis. Effective cell-targeted therapeutics are needed, but the cellular origin of BMF remains elusive. Here, we show using genetic fate tracing in two murin...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Stem Cell
Hlavní autoři: Schneider, Rebekka K., Mullally, Ann, Dugourd, Aurelien, Peisker, Fabian, Hoogenboezem, Remco, Van Strien, Paulina M. H., Bindels, Eric M., Heckl, Dirk, Büsche, Guntram, Fleck, David, Müller-Newen, Gerhard, Wongboonsin, Janewit, Ventura Ferreira, Monica, Puelles, Victor G., Saez-Rodriguez, Julio, Ebert, Benjamin L., Humphreys, Benjamin D., Kramann, Rafael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485654/
https://ncbi.nlm.nih.gov/pubmed/28457748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.03.008
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky