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SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularisation in a rat model of Retinopathy of Prematurity

PURPOSE: We tested the hypothesis that recombinant human VEGF-A(165)b and the serine arginine protein kinase (SRPK) inhibitor, SRPIN340, which controls splicing of the VEGF-A pre-mRNA, prevent neovascularisation in a rodent model of retinopathy of prematurity (ROP). METHODS: In the 50/10 oxygen-indu...

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Publicat a:Invest Ophthalmol Vis Sci
Autors principals: Gammons, Melissa V.R., Dick, Andrew. D., Harper, Steven. J., Bates, David. O.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485497/
https://ncbi.nlm.nih.gov/pubmed/23761094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-11634
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