VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo

BACKGROUND: The key mediator of new vessel formation in cancer and other diseases is VEGF-A. VEGF-A exists as alternatively spliced isoforms - the pro-angiogenic VEGF(xxx) family generated by exon 8 proximal splicing, and a sister family, termed VEGF(xxx)b, exemplified by VEGF(165)b, generated by di...

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Detalhes bibliográficos
Main Authors: Rennel, E S, Varey, A H R, Churchill, A J, Wheatley, E R, Stewart, L, Mather, S, Bates, D O, Harper, S J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768092/
https://ncbi.nlm.nih.gov/pubmed/19707198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605249
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