WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing

Angiogenesis is regulated by the balance of pro-angiogenic VEGF(165) and anti-angiogenic VEGF(165)b splice isoforms. Mutations in WT1, the Wilms’ tumour suppressor gene, suppress VEGF(165)b and cause abnormal gonadogenesis, renal failure and Wilms’ tumours. In WT1 mutant cells, reduced VEGF(165)b wa...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Amin, Elianna M, Oltean, Sebastian, Hua, Jing, Gammons, Melissa VR, Hamdollah-Zadeh, Maryam, Welsh, Gavin I, Cheung, Man-Kim, Ni, Lan, Kase, Satoru, Rennel, Emma S, Symonds, Kirsty E, Nowak, Dawid G, Pokora-Royer, Brigitte, Saleem, Moin A, Hagiwara, Masatoshi, Schumacher, Valérie A, Harper, Steven J, Hinton, David R, Bates, David O, Ladomery, Michael R
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574979/
https://ncbi.nlm.nih.gov/pubmed/22172722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.10.016
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