WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing

Angiogenesis is regulated by the balance of pro-angiogenic VEGF(165) and anti-angiogenic VEGF(165)b splice isoforms. Mutations in WT1, the Wilms’ tumour suppressor gene, suppress VEGF(165)b and cause abnormal gonadogenesis, renal failure and Wilms’ tumours. In WT1 mutant cells, reduced VEGF(165)b wa...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Amin, Elianna M, Oltean, Sebastian, Hua, Jing, Gammons, Melissa VR, Hamdollah-Zadeh, Maryam, Welsh, Gavin I, Cheung, Man-Kim, Ni, Lan, Kase, Satoru, Rennel, Emma S, Symonds, Kirsty E, Nowak, Dawid G, Pokora-Royer, Brigitte, Saleem, Moin A, Hagiwara, Masatoshi, Schumacher, Valérie A, Harper, Steven J, Hinton, David R, Bates, David O, Ladomery, Michael R
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574979/
https://ncbi.nlm.nih.gov/pubmed/22172722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.10.016
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים