Lanean...
WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing
Angiogenesis is regulated by the balance of pro-angiogenic VEGF(165) and anti-angiogenic VEGF(165)b splice isoforms. Mutations in WT1, the Wilms’ tumour suppressor gene, suppress VEGF(165)b and cause abnormal gonadogenesis, renal failure and Wilms’ tumours. In WT1 mutant cells, reduced VEGF(165)b wa...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2011
|
| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574979/ https://ncbi.nlm.nih.gov/pubmed/22172722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.10.016 |
| Etiketak: |
Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
|