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WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing

Angiogenesis is regulated by the balance of pro-angiogenic VEGF(165) and anti-angiogenic VEGF(165)b splice isoforms. Mutations in WT1, the Wilms’ tumour suppressor gene, suppress VEGF(165)b and cause abnormal gonadogenesis, renal failure and Wilms’ tumours. In WT1 mutant cells, reduced VEGF(165)b wa...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Amin, Elianna M, Oltean, Sebastian, Hua, Jing, Gammons, Melissa VR, Hamdollah-Zadeh, Maryam, Welsh, Gavin I, Cheung, Man-Kim, Ni, Lan, Kase, Satoru, Rennel, Emma S, Symonds, Kirsty E, Nowak, Dawid G, Pokora-Royer, Brigitte, Saleem, Moin A, Hagiwara, Masatoshi, Schumacher, Valérie A, Harper, Steven J, Hinton, David R, Bates, David O, Ladomery, Michael R
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574979/
https://ncbi.nlm.nih.gov/pubmed/22172722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.10.016
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