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WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing
Angiogenesis is regulated by the balance of pro-angiogenic VEGF(165) and anti-angiogenic VEGF(165)b splice isoforms. Mutations in WT1, the Wilms’ tumour suppressor gene, suppress VEGF(165)b and cause abnormal gonadogenesis, renal failure and Wilms’ tumours. In WT1 mutant cells, reduced VEGF(165)b wa...
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574979/ https://ncbi.nlm.nih.gov/pubmed/22172722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.10.016 |
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