WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing

Angiogenesis is regulated by the balance of pro-angiogenic VEGF(165) and anti-angiogenic VEGF(165)b splice isoforms. Mutations in WT1, the Wilms’ tumour suppressor gene, suppress VEGF(165)b and cause abnormal gonadogenesis, renal failure and Wilms’ tumours. In WT1 mutant cells, reduced VEGF(165)b wa...

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Main Authors: Amin, Elianna M, Oltean, Sebastian, Hua, Jing, Gammons, Melissa VR, Hamdollah-Zadeh, Maryam, Welsh, Gavin I, Cheung, Man-Kim, Ni, Lan, Kase, Satoru, Rennel, Emma S, Symonds, Kirsty E, Nowak, Dawid G, Pokora-Royer, Brigitte, Saleem, Moin A, Hagiwara, Masatoshi, Schumacher, Valérie A, Harper, Steven J, Hinton, David R, Bates, David O, Ladomery, Michael R
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574979/
https://ncbi.nlm.nih.gov/pubmed/22172722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.10.016
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