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SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularisation in a rat model of Retinopathy of Prematurity
PURPOSE: We tested the hypothesis that recombinant human VEGF-A(165)b and the serine arginine protein kinase (SRPK) inhibitor, SRPIN340, which controls splicing of the VEGF-A pre-mRNA, prevent neovascularisation in a rodent model of retinopathy of prematurity (ROP). METHODS: In the 50/10 oxygen-indu...
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| Veröffentlicht in: | Invest Ophthalmol Vis Sci |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6485497/ https://ncbi.nlm.nih.gov/pubmed/23761094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-11634 |
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