Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD

PURPOSE. Exudative AMD (wet AMD) is treated by monthly injection into the eye of anti-VEGF proteins. VEGF is alternatively spliced to produce numerous isoforms that differ in angiogenic activity. Serine-rich protein kinase-1 (SRPK1) has been identified as a regulator of pro-angiogenic VEGF splicing...

Full description

Saved in:
Bibliographic Details
Main Authors: Gammons, Melissa V., Fedorov, Oleg, Ivison, David, Du, Chunyun, Clark, Tamsyn, Hopkins, Claire, Hagiwara, Masatoshi, Dick, Andrew D., Cox, Russell, Harper, Steven J., Hancox, Jules C., Knapp, Stefan, Bates, David O.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2013
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771558/
https://ncbi.nlm.nih.gov/pubmed/23887803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12422
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items