Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD

PURPOSE. Exudative AMD (wet AMD) is treated by monthly injection into the eye of anti-VEGF proteins. VEGF is alternatively spliced to produce numerous isoforms that differ in angiogenic activity. Serine-rich protein kinase-1 (SRPK1) has been identified as a regulator of pro-angiogenic VEGF splicing...

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Hauptverfasser: Gammons, Melissa V., Fedorov, Oleg, Ivison, David, Du, Chunyun, Clark, Tamsyn, Hopkins, Claire, Hagiwara, Masatoshi, Dick, Andrew D., Cox, Russell, Harper, Steven J., Hancox, Jules C., Knapp, Stefan, Bates, David O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771558/
https://ncbi.nlm.nih.gov/pubmed/23887803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12422
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