Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms

The polyketide natural product borrelidin 1 is a potent inhibitor of angiogenesis and spontaneous metastasis. Affinity biopanning of a phage display library of colon tumor cell cDNAs identified the tandem WW domains of spliceosome-associated protein formin binding protein 21 (FBP21) as a novel molec...

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Hauptverfasser: Woolard, Jeanette, Vousden, William, Moss, Steven J., Krishnakumar, Arjun, Gammons, Melissa VR, Nowak, David G, Dixon, Neil, Micklefield, Jason, Spannhoff, Astrid, Bedford, Mark T., Gregory, Matthew A., Martin, Christine J., Leadlay, Peter F., Zhang, Ming Q., Harper, Steven J., Bates, David O., Wilkinson, Barrie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399765/
https://ncbi.nlm.nih.gov/pubmed/22822423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C0SC00297F
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