Enantioselective Synthesis of Chiral Cyclopent‐2‐enones by Nickel‐Catalyzed Desymmetrization of Malonate Esters

The enantioselective synthesis of highly functionalized chiral cyclopent‐2‐enones by the reaction of alkynyl malonate esters with arylboronic acids is described. These desymmetrizing arylative cyclizations are catalyzed by a chiral phosphinooxazoline/nickel complex, and cyclization is enabled by the...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Karad, Somnath Narayan, Panchal, Heena, Clarke, Christopher, Lewis, William, Lam, Hon Wai
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485403/
https://ncbi.nlm.nih.gov/pubmed/29768708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201805578
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky