Enantioselective Nickel‐Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization

Enantioselective nickel‐catalyzed arylative cyclizations of substrates containing a Z‐allylic phosphate tethered to an alkyne are described. These reactions give multisubstituted chiral aza‐ and carbocycles, and are initiated by the addition of an arylboronic acid to the alkyne, followed by cyclizat...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Yap, Connor, Lenagh‐Snow, Gabriel M. J., Karad, Somnath Narayan, Lewis, William, Diorazio, Louis J., Lam, Hon Wai
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499723/
https://ncbi.nlm.nih.gov/pubmed/28544752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201703380
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