Enantioselective Nickel‐Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization

Enantioselective nickel‐catalyzed arylative cyclizations of substrates containing a Z‐allylic phosphate tethered to an alkyne are described. These reactions give multisubstituted chiral aza‐ and carbocycles, and are initiated by the addition of an arylboronic acid to the alkyne, followed by cyclizat...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Yap, Connor, Lenagh‐Snow, Gabriel M. J., Karad, Somnath Narayan, Lewis, William, Diorazio, Louis J., Lam, Hon Wai
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499723/
https://ncbi.nlm.nih.gov/pubmed/28544752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201703380
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