Enantioselective Nickel‐Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization

Enantioselective nickel‐catalyzed arylative cyclizations of substrates containing a Z‐allylic phosphate tethered to an alkyne are described. These reactions give multisubstituted chiral aza‐ and carbocycles, and are initiated by the addition of an arylboronic acid to the alkyne, followed by cyclizat...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Yap, Connor, Lenagh‐Snow, Gabriel M. J., Karad, Somnath Narayan, Lewis, William, Diorazio, Louis J., Lam, Hon Wai
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499723/
https://ncbi.nlm.nih.gov/pubmed/28544752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201703380
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