Enantioselective synthesis of bicyclo[3.n.1]alkanes by chiral phosphoric acid-catalyzed desymmetrizing Michael cyclizations

2,2-Disubstituted cyclic 1,3-diketones containing a tethered electron-deficient alkene undergo chiral phosphoric acid-catalyzed desymmetrizing Michael cyclizations to give bridged bicyclic products in high enantioselectivities. Both bicyclo[3.2.1]octanes and bicyclo[3.3.1]nonanes are accessible usin...

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Bibliografische gegevens
Gepubliceerd in:Chem Sci
Hoofdauteurs: Burns, Alan R., Madec, Amaël G. E., Low, Darryl W., Roy, Iain D., Lam, Hon Wai
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Royal Society of Chemistry 2015
Onderwerpen:
Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659222/
https://ncbi.nlm.nih.gov/pubmed/29511516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc00753d
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