SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury

Acute lung injury (ALI) is characterized by exuberant proinflammatory responses and mitochondrial dysfunction. However, the link between mitochondrial dysfunction and inflammation in ALI is not well understood. In this report, we demonstrate a critical role for the mitochondrial NAD(+)-dependent dea...

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Vydáno v:JCI Insight
Hlavní autoři: Kurundkar, Deepali, Kurundkar, Ashish R., Bone, Nathaniel B., Becker, Eugene J., Liu, Wanqu, Chacko, Balu, Darley-Usmar, Victor, Zmijewski, Jaroslaw W., Thannickal, Victor J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485358/
https://ncbi.nlm.nih.gov/pubmed/30626741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120722
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