The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury

Matricellular proteins mediate pleiotropic effects during tissue injury and repair. CCN1 is a matricellular protein that has been implicated in angiogenesis, inflammation, and wound repair. In this study, we identified CCN1 as a gene that is differentially up-regulated in alveolar mesenchymal cells...

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Bibliographische Detailangaben
Veröffentlicht in:FASEB J
Hauptverfasser: Kurundkar, Ashish R., Kurundkar, Deepali, Rangarajan, Sunad, Locy, Morgan L., Zhou, Yong, Liu, Rui-Ming, Zmijewski, Jaroslaw, Thannickal, Victor J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871800/
https://ncbi.nlm.nih.gov/pubmed/26884454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500173
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