Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis

Cytotoxic T lymphocyte (CTL) activation contributes to liver damage during sepsis, but the mechanisms involved are largely unknown. Understanding the underlying principle will permit interference with CTL activation and thus, provide a new therapeutic option. Methods: To elucidate the mechanism lead...

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發表在:Theranostics
Main Authors: von Knethen, Andreas, Schäfer, Anne, Kuchler, Laura, Knape, Tilo, Christen, Urs, Hintermann, Edith, Fißlthaler, Beate, Schröder, Katrin, Brandes, Ralf P., Genz, Berit, Abshagen, Kerstin, Pützer, Brigitte M., Sha, Lisa K., Weigert, Andreas, Syed, Shahzad N., Schulz, Martin, Shah, Ajay M., Ernst, Andreas, Putyrski, Mateusz, Finkelmeier, Fabian, Pesic, Marina, Greten, Florian, Hogardt, Michael, Kempf, Volkhard A. J., Gunne, Sandra, Parnham, Michael J., Brüne, Bernhard
格式: Artigo
語言:Inglês
出版: Ivyspring International Publisher 2019
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485280/
https://ncbi.nlm.nih.gov/pubmed/31037153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.28057
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