Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis

Cytotoxic T lymphocyte (CTL) activation contributes to liver damage during sepsis, but the mechanisms involved are largely unknown. Understanding the underlying principle will permit interference with CTL activation and thus, provide a new therapeutic option. Methods: To elucidate the mechanism lead...

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Publicat a:Theranostics
Autors principals: von Knethen, Andreas, Schäfer, Anne, Kuchler, Laura, Knape, Tilo, Christen, Urs, Hintermann, Edith, Fißlthaler, Beate, Schröder, Katrin, Brandes, Ralf P., Genz, Berit, Abshagen, Kerstin, Pützer, Brigitte M., Sha, Lisa K., Weigert, Andreas, Syed, Shahzad N., Schulz, Martin, Shah, Ajay M., Ernst, Andreas, Putyrski, Mateusz, Finkelmeier, Fabian, Pesic, Marina, Greten, Florian, Hogardt, Michael, Kempf, Volkhard A. J., Gunne, Sandra, Parnham, Michael J., Brüne, Bernhard
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485280/
https://ncbi.nlm.nih.gov/pubmed/31037153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.28057
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