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Two alternative mechanisms regulate the onset of chaperone-mediated assembly of the proteasomal ATPases

The proteasome holoenzyme is a molecular machine that degrades most proteins in eukaryotes. In the holoenzyme, its heterohexameric ATPase injects protein substrates into the proteolytic core particle, where degradation occurs. The heterohexameric ATPase, referred to as 'Rpt ring', assemble...

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Foilsithe in:J Biol Chem
Main Authors: Nahar, Asrafun, Fu, Xinyi, Polovin, George, Orth, James D., Park, Soyeon
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484131/
https://ncbi.nlm.nih.gov/pubmed/30814255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006298
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