Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly

In the proteasome, the proteolytic 20S core particle (CP) associates with the 19S regulatory particle (RP) to degrade polyubiquitinated proteins. Six ATPases (Rpt1-Rpt6) of the RP form a hexameric Rpt ring and interact with the heptameric α ring (α1–α7) of the CP via the Rpt C-terminal tails individ...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Sokolova, Vladyslava, Li, Frances, Polovin, George, Park, Soyeon
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598862/
https://ncbi.nlm.nih.gov/pubmed/26449534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14909
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