Ubiquitin-dependent switch during assembly of the proteasomal ATPases mediated by Not4 ubiquitin ligase

In the proteasome holoenzyme, the hexameric ATPases (Rpt1-Rpt6) enable degradation of ubiquitinated proteins by unfolding and translocating them into the proteolytic core particle. During early-stage proteasome assembly, individual Rpt proteins assemble into the hexameric “Rpt ring” through binding...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Fu, Xinyi, Sokolova, Vladyslava, Webb, Kristofor J., Old, William, Park, Soyeon
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310792/
https://ncbi.nlm.nih.gov/pubmed/30530678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805353115
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