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Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea
Diarrhea is a major side effect of ErbB receptor tyrosine kinase inhibitors (TKIs) in cancer chemotherapy. Here, we show that the primary mechanism of ErbB TKI diarrhea is activation of basolateral membrane potassium (K(+)) channels and apical membrane chloride (Cl(–)) channels in intestinal epithel...
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| Pubblicato in: | JCI Insight |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478423/ https://ncbi.nlm.nih.gov/pubmed/30668547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126444 |
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